Nuclear fission — the physical process that makes nuclear weapons and nuclear power possible — was discovered in December 1938 by the German chemists Otto Hahn and Fritz Strassmann, working in Berlin, with the theoretical interpretation of their results supplied shortly afterward by the Austrian-Swedish physicist Lise Meitner and her nephew Otto Frisch, both of whom had fled Nazi persecution. Germany therefore held, at least on paper, an early scientific lead: the discovery happened on German soil, and Germany's physics establishment, including figures like Werner Heisenberg, was among the strongest in the world. A German nuclear research effort, later known as the Uranverein or 'Uranium Club', began within months of the discovery, coordinated loosely under military and academic authority.
That early lead evaporated over the following six years for a well-documented combination of reasons. Nazi racial policy had already driven a substantial share of Germany's most capable physicists — including Meitner, Frisch, Albert Einstein, and many others — into exile well before the war began, a self-inflicted loss of exactly the expertise a weapons program would have needed most. The German program itself never received anything close to the resourcing, urgency, or centralized organization the American Manhattan Project eventually did; it remained smaller in scale, divided between competing institutional interests, and hampered by miscalculations in the underlying physics that led German researchers to overestimate how much material and effort a working weapon would require. A heavy-water production facility at Vemork in occupied Norway, considered essential to Germany's approach, was disabled by Norwegian resistance fighters and Allied bombing raids across 1943, further setting the program back. By the time American and British forces overran German nuclear research sites in 1945 — documented by the Allied Alsos Mission sent specifically to assess German progress — it was clear Germany had remained years away from a functioning weapon. The American Manhattan Project, by contrast, had grown into an industrial undertaking employing over 130,000 people at its peak and costing roughly $2 billion in 1940s dollars — equivalent to well over $30 billion today — before successfully testing its first device at Trinity, New Mexico, on July 16, 1945.